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Current Drug Targets - Inflammation & Allergy


ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Oxidative Stress-Related Molecules as a Therapeutic Target for Inflammatory and Allergic Diseases

Author(s): Y. Naito, H. Takano and T. Yoshikawa

Volume 4, Issue 4, 2005

Page: [511 - 515] Pages: 5

DOI: 10.2174/1568010054526269

Price: $65


There is a growing body of evidence that oxidative stress mediated by reactive oxygen species plays an important role in the pathogenesis of various kinds of allergic and non-allergic inflammation. These data suggest that blocking reactive oxygen species should be useful for amelioration of allergic or non-allergic inflammation in the respiratory and intestinal tracts. In addition, the modulation of oxidative stress-related molecules, such as inducible nitric oxide synthase and redox-sensitive transcriptional factors, may be useful for the regulation of these inflammatory responses. In this review, we have summarized the recent advances in the prevention of allergic or non-allergic inflammation, especially the diesel exhaust particle-induced respiratory allergic response and dextran sulfate sodium-induced intestinal inflammation in rodents.

Keywords: antioxidant, inducible nitric oxide synthase, nuclear factor, oxidative stress

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