Abstract
In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given the viability of the parenchyma. In particular, a chain of microcirculatory events will be described which - after specific endothelial activation by growth factors – enhances capillary and microcirculatory vessel formation, Backward signalling is introduced as potential mechanism to induce collateral growth, recruiting pre-existent macrovessel networks for blood supply to the increased microcirculatory cross sectional area. Potential signal cascades will be discussed.
Keywords: Angiogenesis, arteriogenesis, vasculogenesis, VEGF, eNOS, endothelial progenitor cells, vessel maturation, inflammation
Current Pharmaceutical Biotechnology
Title: The Vascular Compartments of Neovascularization: Spotlight on the Microcirculation
Volume: 8 Issue: 1
Author(s): Christian Kupatt
Affiliation:
Keywords: Angiogenesis, arteriogenesis, vasculogenesis, VEGF, eNOS, endothelial progenitor cells, vessel maturation, inflammation
Abstract: In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given the viability of the parenchyma. In particular, a chain of microcirculatory events will be described which - after specific endothelial activation by growth factors – enhances capillary and microcirculatory vessel formation, Backward signalling is introduced as potential mechanism to induce collateral growth, recruiting pre-existent macrovessel networks for blood supply to the increased microcirculatory cross sectional area. Potential signal cascades will be discussed.
Export Options
About this article
Cite this article as:
Kupatt Christian, The Vascular Compartments of Neovascularization: Spotlight on the Microcirculation, Current Pharmaceutical Biotechnology 2007; 8 (1) . https://dx.doi.org/10.2174/138920107779941390
DOI https://dx.doi.org/10.2174/138920107779941390 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
Latest Advancements in Biotherapeutics
The scope of this thematic issue is to comprehensively explore the rapidly evolving landscape of biotherapeutics, emphasizing breakthroughs in precision medicine. Encompassing diverse therapeutic modalities, the issue will delve into the latest developments in monoclonal antibodies, CRISPR/Cas gene editing, CAR-T cell therapies, and innovative drug delivery systems, such as nanoparticle-based ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lipid Lowering Therapy in the Elderly: Is there a Benefit?
Current Pharmaceutical Design Status of Cytokines in Ischemia Reperfusion Induced Heart Injury
Cardiovascular & Hematological Disorders-Drug Targets Disturbed Homeostasis in Patients with Acute Psychosis
Current Psychiatry Reviews General Aspects of Metal Toxicity
Current Medicinal Chemistry Update on the Pathophysiological Role of Intracellular Signaling Pathways in Atherosclerotic Plaques and Ischemic Myocardium
Current Signal Transduction Therapy Soluble Epoxide Hydrolase, a Target with Multiple Opportunities for Cardiovascular Drug Discovery
Current Topics in Medicinal Chemistry Prevalence, Incidence, Risk and Protective Factors of Amnestic Mild Cognitive Impairment in the Elderly in Shanghai
Current Alzheimer Research Hyperhomocysteinemia and Sudden Cardiac Death: Potential Arrhythmogenic Mechanisms
Current Vascular Pharmacology Emerging Vascular Risk Factors in Women: Any Differences from Men?
Current Medicinal Chemistry Risk Factors for Myocardial Infarction in Women and Men: A Review of the Current Literature
Current Pharmaceutical Design Nano-Systems for Advanced Therapeutics and Diagnosis of Atherosclerosis
Current Pharmaceutical Design Novel Drugs and the Response to Hypoxia: HIF Stabilizers and Prolyl Hydroxylase
Recent Patents on Cardiovascular Drug Discovery Obesity and Heart Failure
Endocrine, Metabolic & Immune Disorders - Drug Targets Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions
Current Genomics Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Current Neuropharmacology Diadenosine Polyphosphates: Postulated Mechanisms Mediating the Cardiac Effects
Current Medicinal Chemistry - Cardiovascular & Hematological Agents The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Perioperative Management of Intracranial Aneurysm and Subarachnoid Hemorrhage
Current Pharmaceutical Design Estrogenic Compounds, Estrogen Receptors and Vascular Cell Signaling in the Aging Blood Vessels
Current Medicinal Chemistry Strategies for Leukotriene Modulation in Dermatology: Even More Visionary Perspectives? An Update
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry