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Current Drug Targets - Infectious Disorders

Editor-in-Chief

ISSN (Print): 1568-0053
ISSN (Online): 1875-5852

Novel Tissue and Cell Type-specific Gene / Drug Delivery System Using Surface Engineered Hepatitis B Virus Nano-particles

Author(s): Tadanori Yamada, Masakazu Ueda, Masaharu Seno, Akihiko Kondo, Katsuyuki Tanizawa and Shun'ichi Kuroda

Volume 4, Issue 2, 2004

Page: [163 - 167] Pages: 5

DOI: 10.2174/1568005043341037

Price: $65

Abstract

The hepatitis B virus (HBV) surface antigen (HBsAg) L particle is a hollow nano-scale particle. HBsAg L particles have many properties that make them useful for in vivo gene transfer vectors and drug delivery systems. Gene therapy so far has required the in vivo pinpoint delivery of genetic materials into the target organs and cells. Gene transfer by HBsAg L particles might be an attractive method, since their tropism is the same as that of HBV. The HBsAg L particles are able to deliver therapeutic payloads with high specificity to human hepatocytes. In addition, the specificity of L particle can be altered by displaying various cell-binding molecules on the surface. Our results indicate that the L particle is suitable for a cell- and tissue-specific gene / drug transfer vector. In this review, we discuss HBsAg L particles as a gene / drug transfer vector and its potential for the treatment of infectious diseases.

Keywords: hbsag l particle, gene delivery, drug system, in vivo system

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