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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis

Author(s): Elizabeth Z. Managlia, Deborah Carroll, Andrew Zloza and Lena Al-Harthi

Volume 2, Issue 4, 2004

Page: [395 - 401] Pages: 7

DOI: 10.2174/1570162043351020

Price: $65


Much attention has been focused on CD4+ memory / primed T cells and monocytes / macrophages as the predominant targets of HIV infection. Considerable evidence, however, indicates that cell types that are classically not permissive to HIV infection, can be a potent source of productive virus replication in response to immune modulation. This immune modulation can be in the form of cytokine stimulation pre- or postinfection or by activating these “non-conventional” targets. In this review, we will provide evidence for immune modulation of HIV infection with special emphasis on immune modulation of HIV replication in classically non-HIV permissive primary cells of both lymphoid and non-lymphoid origins. We will also examine the impact of HIV infection of these non-conventional targets as they pertain to both HIV immunoand neuro-pathogenesis.

Keywords: immune reconstitution, cytokine therapy, hiv, neuropathogenesis

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