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Current Drug Targets - Inflammation & Allergy


ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Mast Cell-IgE-and Mast Cell-Structural Cell Interactions in Allergic Airway Disease

Author(s): Ruby Pawankar, Shigeo Yamagishi, Ryuta Takizawa and Toshiaki Yagi

Volume 2, Issue 4, 2003

Page: [303 - 312] Pages: 10

DOI: 10.2174/1568010033484016

Price: $65


Allergic diseases like atopic rhinitis, bronchial asthma, and urticaria are prevalent and on the rise. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators like histamine, leukotrienes, and prostaglandins. On the other hand, T lymphocytes, basophils and eosinophils are thought to be responsible in inducing the late phase response. Yet, recent studies show that the mast cell cannot be simplistically assigned a role in the immediate phase allergic response, and that this cell plays a crucial role in ongoing allergic inflammation, including the development of hyper-responsiveness. In the present article, the author will try to discuss the integrated roles of mast cells in IgEmediated allergic inflammation with specific emphasis on the roles of mast cell-IgE networking and mast cellstructural cell interactions in the late phase allergic response and chronic allergic inflammation.

Keywords: allergy, mast cell, local Ige synthesis, integrins, epithelial cells

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