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Current Drug Targets - Inflammation & Allergy


ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Therapeutic Approaches to Chronic Intestinal Inflammation by Specific Targeting of Mucosal IL-7 / IL-7R Signal Pathway

Author(s): Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura and Takanori Kanai

Volume 2, Issue 2, 2003

Page: [119 - 123] Pages: 5

DOI: 10.2174/1568010033484269

Price: $65


Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)+ mucosal lymphocytes. The pivotal role of mucosal IL-7 / IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7 / IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.

Keywords: il-7, il-7 receptor, t cells, mucosal immunity, ibd

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