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Current Medicinal Chemistry - Anti-Infective Agents


ISSN (Print): 1568-0126
ISSN (Online): 1875-600X

A Review of Recent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Research Activity

Author(s): Jeffrey W. Corbett

Volume 1, Issue 2, 2002

Page: [119 - 140] Pages: 22

DOI: 10.2174/1568012023354938

Price: $65


This non-nucleoside reverse transcriptase inhibitor review covers the patent and published literature from January, 1998-August, 2001. Major advances have been made in the past decade in discovering non-nucleoside reverse transcriptase inhibitors that are effective in inhibiting replication of wild-type virus. Attention is now focused upon the discovery of agents that are effective in inhibiting replication of virus with singly and doubly mutated HIV-1 reverse transcriptase. Notable advances in the discovery of such broad spectrum therapeutics are SG-153 and the quinazolines DPC961 and DPC083. Attempts at discovering other broad spectrum anti-viral agents are presented herein.

Keywords: Hiv-1 non-nucleoside reverse transcriptase inhibitor, nnrti, stavudine

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