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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Tyrosine Kinase Mutations in Human Cancer

Author(s): Ernst Lengyel, Kenjiro Sawada and Ravi Salgia

Volume 7, Issue 1, 2007

Page: [77 - 84] Pages: 8

DOI: 10.2174/156652407779940486

Price: $65


A subset of tyrosine kinases are activated by mutations which contribute to the malignant transformation, growth, and metastasis of human cancers. Mutations change the expression, conformation and/or stability of tyrosine kinases, often leading to constitutive activation of the signaling pathways the kinases regulate. Given that tyrosine kinases are key members of signaling cascades, mutations have multiple effects on various cellular proteins. This review will focus on four kinases (EGFR, c-Met, c-Kit, and PI3-kinase) known to be mutated in human cancer. It will discuss the effects that these mutations have on the biology of tumors, and how our understanding of the structure and function of kinases and their mutations is currently being used to design targeted treatments.

Keywords: Mutation, EGFR, PI3-kinase, c-Met, tyrosine kinase, NSCLC, ovarian cancer

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