Metabolite Interference in Pharmacokinetic Studies

Title: Metabolite Interference in Pharmacokinetic Studies

Volume: 1 Issue: 4

Author(s): Mehran F. Moghaddam, Jui-Hsiang Fan, Yang Tang, Oleg Khatsenko, Jason C. Katz and Michael A. Shirley

Affiliation:

Keywords: Pharmacokinetics, metabolite, isomer, chromatography, coelution, aminocyclohexanol

Abstract: Our policy of conducting biotransformation studies with extended chromatography prior to pharmacokinetic bioanalyses allowed us to quickly detect an unusual, cis/trans metabolite in rat plasma that was inseparable using a short chromatographic method. We caution investigators that short methods invite unknown isobaric metabolites to cause inaccuracies in plasma concentration measurements.

Cite this article as:

Moghaddam F. Mehran, Fan Jui-Hsiang, Tang Yang, Khatsenko Oleg, Katz C. Jason and Shirley A. Michael, Metabolite Interference in Pharmacokinetic Studies, Drug Metabolism Letters 2007; 1 (4) . https://dx.doi.org/10.2174/187231207783221475