Abstract
Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.
Keywords: HIV, nef, fitness, pathogenesis, replication
Current HIV Research
Title: HIV Nef: Role in Pathogenesis and Viral Fitness
Volume: 6 Issue: 3
Author(s): Kevin K. Arien and Bruno Verhasselt
Affiliation:
Keywords: HIV, nef, fitness, pathogenesis, replication
Abstract: Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.
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Cite this article as:
Arien K. Kevin and Verhasselt Bruno, HIV Nef: Role in Pathogenesis and Viral Fitness, Current HIV Research 2008; 6 (3) . https://dx.doi.org/10.2174/157016208784325001
DOI https://dx.doi.org/10.2174/157016208784325001 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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