Abstract
The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from longterm nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.
Keywords: HIV-1, viral protein R (Vpr), viral transcription, apoptosis, cell cycle arrest, mitochondrial membrane potential and immune suppression
Current HIV Research
Title: HIV-1 Vpr: Regulator of Viral Survival
Volume: 7 Issue: 2
Author(s): Khanh P. Thieu, Matthew P. Morrow, Devon J. Shedlock, Kimberly A. Schoenly, Karthikbabu Mallilankaraman, Andrew Y. Choo, Paolo Fagone, David B. Weiner and Karuppiah Muthumani
Affiliation:
Keywords: HIV-1, viral protein R (Vpr), viral transcription, apoptosis, cell cycle arrest, mitochondrial membrane potential and immune suppression
Abstract: The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from longterm nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.
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Cite this article as:
Thieu P. Khanh, Morrow P. Matthew, Shedlock J. Devon, Schoenly A. Kimberly, Mallilankaraman Karthikbabu, Choo Y. Andrew, Fagone Paolo, Weiner B. David and Muthumani Karuppiah, HIV-1 Vpr: Regulator of Viral Survival, Current HIV Research 2009; 7 (2) . https://dx.doi.org/10.2174/157016209787581454
DOI https://dx.doi.org/10.2174/157016209787581454 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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