Abstract
Polymer based therapies offer many potential advantages in the treatment of diseases of the nervous system, and would allow delivery of therapeutic agents directly to the relevant area of brain, circumventing obstacles presented by the blood brain barrier, avoiding the side-effects often associated with systemic medication administration, and permitting much smaller doses of medication. As improvements in diagnostic procedures, particularly imaging, now provide very accurate localization of therapeutic targets in many of these conditions, it is technically feasible to deliver such agents precisely to the relevant brain region. Combined with advances in polymer sciences, there is renewed interest in focal drug delivery systems, particularly around intelligent or controlled release systems which would extend the life-span of these devices considerably. Major obstacles remain, however, particularly around the safety and biocompatibility of such materials, and the complexity of testing in clinical scenarios. We review here the current status of animal and human studies in this rapidly evolving area, addressing some of the practical obstacles and examining the range of potential applications in chronic neurological disease.
Keywords: Neurological disorders, Parkinson's disease, Alzheimer's disease, Huntington's disease, polymer, drug delivery, epilepsy, implantable devices
CNS & Neurological Disorders - Drug Targets
Title: Polymer-Based Drug Delivery Devices for Neurological Disorders
Volume: 8 Issue: 3
Author(s): A. J. Halliday and M. J. Cook
Affiliation:
Keywords: Neurological disorders, Parkinson's disease, Alzheimer's disease, Huntington's disease, polymer, drug delivery, epilepsy, implantable devices
Abstract: Polymer based therapies offer many potential advantages in the treatment of diseases of the nervous system, and would allow delivery of therapeutic agents directly to the relevant area of brain, circumventing obstacles presented by the blood brain barrier, avoiding the side-effects often associated with systemic medication administration, and permitting much smaller doses of medication. As improvements in diagnostic procedures, particularly imaging, now provide very accurate localization of therapeutic targets in many of these conditions, it is technically feasible to deliver such agents precisely to the relevant brain region. Combined with advances in polymer sciences, there is renewed interest in focal drug delivery systems, particularly around intelligent or controlled release systems which would extend the life-span of these devices considerably. Major obstacles remain, however, particularly around the safety and biocompatibility of such materials, and the complexity of testing in clinical scenarios. We review here the current status of animal and human studies in this rapidly evolving area, addressing some of the practical obstacles and examining the range of potential applications in chronic neurological disease.
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Cite this article as:
Halliday J. A. and Cook J. M., Polymer-Based Drug Delivery Devices for Neurological Disorders, CNS & Neurological Disorders - Drug Targets 2009; 8 (3) . https://dx.doi.org/10.2174/187152709788680698
DOI https://dx.doi.org/10.2174/187152709788680698 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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