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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals

Author(s): Oswald Moling, Giovanni Rimenti, Raffaele Pristera, Claudio Vedovelli, Leonardo Pagani, Greta Spoladore and Peter Mian

Volume 3, Issue 3, 2009

Page: [176 - 180] Pages: 5

DOI: 10.2174/187231209789352120

Price: $65


A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.

Keywords: Lactic acidosis, nifedipine, disulfiram, amitriptyline, ritonavir, HIV

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