Abstract
Molecular imaging via Single Photon Emission Computed Tomography (SPECT) holds considerable promise for analysis of metabolism and bio-distribution of drugs in addition to imaging of diseased states. While the related Positron Emission Tomography (PET) imaging offers higher resolution images, SPECT is considered the more practical approach to nuclear imaging for routine diagnostic use. One of the attractive features of SPECT is its utilization of medium to long-lived radioisotopes, particularly radio-iodinated species. This mini-review will survey recent advances in radioiodination, including synthetic chemistry and post-labeling purification methods.
Keywords: SPECT, radiochemistry, radioiodination, radiolabeling, radioisotopes, halodestannylation, halodethallation, fluorous labelling
Current Radiopharmaceuticals
Title: Radio-Iodination Methods for the Production of SPECT Imaging Agents
Volume: 3 Issue: 1
Author(s): K. M. Wager and G. B. Jones
Affiliation:
Keywords: SPECT, radiochemistry, radioiodination, radiolabeling, radioisotopes, halodestannylation, halodethallation, fluorous labelling
Abstract: Molecular imaging via Single Photon Emission Computed Tomography (SPECT) holds considerable promise for analysis of metabolism and bio-distribution of drugs in addition to imaging of diseased states. While the related Positron Emission Tomography (PET) imaging offers higher resolution images, SPECT is considered the more practical approach to nuclear imaging for routine diagnostic use. One of the attractive features of SPECT is its utilization of medium to long-lived radioisotopes, particularly radio-iodinated species. This mini-review will survey recent advances in radioiodination, including synthetic chemistry and post-labeling purification methods.
Export Options
About this article
Cite this article as:
Wager K. M. and Jones G. B., Radio-Iodination Methods for the Production of SPECT Imaging Agents, Current Radiopharmaceuticals 2010; 3 (1) . https://dx.doi.org/10.2174/1874471011003010037
DOI https://dx.doi.org/10.2174/1874471011003010037 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nonviral Approach for Targeted Nucleic Acid Delivery
Current Medicinal Chemistry Gene Therapy for Haemophagocytic Lymphohistiocytosis
Current Gene Therapy Nanochannel Systems for Personalized Therapy and Laboratory Diagnostics
Current Pharmaceutical Biotechnology The Protein-Protein Interaction-Mediated Inactivation of PTEN
Current Molecular Medicine Clinical Pharmacology of Serotonin Receptor Type 3 (5-HT3) Antagonists
Current Medicinal Chemistry - Central Nervous System Agents Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications
Current Topics in Medicinal Chemistry Oncolytic Viruses for Induction of Anti-Tumor Immunity
Current Pharmaceutical Biotechnology Heparin Affin Regulatory Peptide: A New Target for Tumour Therapy?
Current Cancer Drug Targets Polymeric Nanomicelles of Soluplus® as a Strategy for Enhancing the Solubility, Bioavailability and Efficacy of Poorly Soluble Active Compounds
Current Nanomedicine Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery
Nanoscience & Nanotechnology-Asia Incorporation of Targeted Agents in the Management of Patients with Advanced Gastric Cancer
Current Medicinal Chemistry Modulation of Matrix Metalloproteinases by Plant-derived Products
Current Cancer Drug Targets An Overview of Compounds Derived from the Shikimate and Phenylpropanoid Pathways and Their Medicinal Importance
Mini-Reviews in Medicinal Chemistry Nanomedicine to Deal With Cancer Cell Biology in Multi-Drug Resistance
Mini-Reviews in Medicinal Chemistry Hypoxia Responsive Drug Delivery Systems in Tumor Therapy
Current Pharmaceutical Design Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties
Current Molecular Medicine Understanding Mouse Skin Carcinogenesis through Transgenic Approaches
Current Genomics The Emerging Role of TRP Channels in Mechanisms of Temperature and Pain Sensation
Current Neuropharmacology Plasmids Encoding Protein Aggregation Domains Act As Molecular Adjuvants for DNA Vaccines
Current Gene Therapy New Insights on the Antitumoral Properties of Prodiginines
Current Medicinal Chemistry