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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Feline Immunodeficiency Virus (FIV) as A Model for Study of Lentivirus Infections: Parallels with HIV

Author(s): John H. Elder, Ying-Chuan Lin, Elizabeth Fink and Chris K. Grant

Volume 8, Issue 1, 2010

Page: [73 - 80] Pages: 8

DOI: 10.2174/157016210790416389

Price: $65


FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.

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