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Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Pre-Clinical and Clinical Aspects of Peptide-based Vaccine Against Human Solid Tumors

Author(s): Seyed Amir Jalali and Giorgio Parmiani

Volume 5, Issue 2, 2011

Page: [108 - 117] Pages: 10

DOI: 10.2174/187220811796365716

Price: $65

Abstract

Peptides deriving from tumor-associated antigens and recognized by patient T cells have been firstly defined in the early 90's, and then used as vaccine in animal models and in cancer patients. Early trials showed a variable, often even high frequency of patients developing peptide-specific T-cell mediated immune response usually accompanied by a lower frequency of clinical response. Modified, long peptides could be synthesized with a higher in vitro binding to the corresponding HLA allele that only seldom translated into a clear improvement in the tumor response. However, we show here that more recent studies of multipeptide-based vaccines resulted in a higher and more robust T cell response causing also a more effective clinical response particularly in melanoma and prostate cancer patients. In this article, we also used some of the recent patents describing different inventions related to pre-clinical and clinical aspects of peptide based vaccines against human solid tumors.

Keywords: Peptides, tumor antigens, vaccination, clinical response, tumor-associated antigens (TAAs), melanoma antigen (MAGE), HLA haplotype, CTL epitope, HLA receptors, high-throughput receptorligand assays, mass spectrometry, cancer-testis (CT), HLA-A2, peptide-based anti-cancer vaccines, peripheral blood mononuclear cells (PBMCs)

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