Abstract
The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation. The tryptophan- degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-maternal interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.
Keywords: Feto-maternal tolerance, tryptophan catabolism, placenta, trophoblast, decidua, preeclampsia, spontaneous abortion
Current Drug Metabolism
Title: Indoleamine 2,3-Dioxygenase in Materno-Fetal Interaction
Volume: 8 Issue: 3
Author(s): Peter Sedlmayr
Affiliation:
Keywords: Feto-maternal tolerance, tryptophan catabolism, placenta, trophoblast, decidua, preeclampsia, spontaneous abortion
Abstract: The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation. The tryptophan- degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-maternal interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.
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Cite this article as:
Sedlmayr Peter, Indoleamine 2,3-Dioxygenase in Materno-Fetal Interaction, Current Drug Metabolism 2007; 8 (3) . https://dx.doi.org/10.2174/138920007780362491
DOI https://dx.doi.org/10.2174/138920007780362491 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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