Abstract
Introduction: Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions. Methods: Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG. Results: Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 μm), lower number of cellular layers (10.41 vs 13.66 μm), lower mean cell diameter (10.09 vs 11.51 μm), less number of total LCs (11.19 vs 23.08 LCs/mm² ), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant. Conclusion: AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease.
Keywords: AIDS, atrophy, epithelium, immunity, uterine cervix, women, tract epithelium, Hematoxylin-eosin, Cellular Layers, cervix
Current HIV Research
Title: The Influence of AIDS on the Morphometric and Immune Status of the Uterine Cervix of Autopsied Patients
Volume: 9 Issue: 8
Author(s): Camila Lourencini Cavellani, Laura Penna Rocha, Simone Cristina da Silva Rosa, Livia Ferreira Oliveira, Humberto Aparecido Faria, Janainna Grazielle Pacheco Olegario, Rosana Rosa Miranda Correa and Vicente de Paula Antunes Teixeira
Affiliation:
Keywords: AIDS, atrophy, epithelium, immunity, uterine cervix, women, tract epithelium, Hematoxylin-eosin, Cellular Layers, cervix
Abstract: Introduction: Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions. Methods: Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG. Results: Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 μm), lower number of cellular layers (10.41 vs 13.66 μm), lower mean cell diameter (10.09 vs 11.51 μm), less number of total LCs (11.19 vs 23.08 LCs/mm² ), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant. Conclusion: AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease.
Export Options
About this article
Cite this article as:
Lourencini Cavellani Camila, Penna Rocha Laura, Cristina da Silva Rosa Simone, Ferreira Oliveira Livia, Aparecido Faria Humberto, Grazielle Pacheco Olegario Janainna, Rosa Miranda Correa Rosana and de Paula Antunes Teixeira Vicente, The Influence of AIDS on the Morphometric and Immune Status of the Uterine Cervix of Autopsied Patients, Current HIV Research 2011; 9 (8) . https://dx.doi.org/10.2174/157016211798998745
DOI https://dx.doi.org/10.2174/157016211798998745 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Systemic Vasculitis: An Epidemiological Perspective
Current Immunology Reviews (Discontinued) Dopamine Administration in Very Low Birth Weight Preterm Infants:Emerging Issues on Endocrine Effects
Current Pediatric Reviews Over-Expression, Solubilization, and Purification of G Protein-Coupled Receptors for Structural Biology
Combinatorial Chemistry & High Throughput Screening The Long Pentraxin PTX3, a Soluble Pattern Recognition Receptor Involved in Innate Immunity,Inflammation and Female Fertility
Current Immunology Reviews (Discontinued) B-lymphocytes as Targets for Therapy in Chronic Cold Agglutinin Disease
Cardiovascular & Hematological Disorders-Drug Targets Non-Alcoholic Steatohepatitis: New Insights from OMICS Studies
Current Pharmaceutical Biotechnology Prevention of Contrast Induced Nephropathy
Current Drug Therapy Oxidative DNA Damage and Oxidant/Anti-Oxidant Enzymatic Systems in Carcinogenesis and Cancer Progression
Current Enzyme Inhibition Alkaloids in the Nature: Pharmacological Applications in Clinical Practice of Berberine and Mate Tea
Current Topics in Medicinal Chemistry Amniotic Fluid Embolism: Moving Diagnosis Through the Time. From the Mechanical Pulmonary Vascular Occlusion Until An Immuno - Inflammatory Pathogenesis?
Current Pharmaceutical Biotechnology Microglial Activation as a Compelling Target for Treating Acute Traumatic Brain Injury
Current Medicinal Chemistry Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis
Current Medicinal Chemistry TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases
Current Drug Targets The Hemodynamics of Septic Shock: A Historical Perspective
Current Vascular Pharmacology Electroporation: An Effective Method For <i>In Vivo</i> Gene Delivery
Drug Delivery Letters Inflammation in Ischemic Stroke: Mechanisms, Consequences and Possible Drug Targets
CNS & Neurological Disorders - Drug Targets Thoughtful Insights into the Therapeutic Armamentarium of Chalcones: 10 Years of Glorious Journey
Current Bioactive Compounds Heart Infection Prognosis Analysis by Two-dimensional Spot Tracking Imaging
Current Medical Imaging Anti-Inflammatory Effects of C-Peptide Prevent Endothelial Dysfunction in Type 1 Diabetes
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Oxidative Stress, Histone Deacetylase and Corticosteroid Resistance in Severe Asthma and COPD
Current Respiratory Medicine Reviews