Abstract
Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.
Keywords: Epothilone, antitumor compounds, total synthesis
Mini-Reviews in Organic Chemistry
Title: Synthetic Methodologies for the Preparation of Epothilones and Analogs
Volume: 3 Issue: 1
Author(s): Inacio Luduvico, Mireille L. Hyaric, Mauro V. De Almeida and Adilson D. Da Silva
Affiliation:
Keywords: Epothilone, antitumor compounds, total synthesis
Abstract: Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.
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Cite this article as:
Luduvico Inacio, Hyaric L. Mireille, De Almeida V. Mauro and Da Silva D. Adilson, Synthetic Methodologies for the Preparation of Epothilones and Analogs, Mini-Reviews in Organic Chemistry 2006; 3 (1) . https://dx.doi.org/10.2174/157019306775474194
DOI https://dx.doi.org/10.2174/157019306775474194 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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