Abstract
Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Current Pharmacogenomics and Personalized Medicine
Title: Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?
Volume: 8 Issue: 2
Author(s): Paul J. Jannetto, Nancy C. Bratanow and Agnieszka Rogalska
Affiliation:
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Abstract: Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
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Cite this article as:
J. Jannetto Paul, C. Bratanow Nancy and Rogalska Agnieszka, Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?, Current Pharmacogenomics and Personalized Medicine 2010; 8 (2) . https://dx.doi.org/10.2174/187569210791383947
DOI https://dx.doi.org/10.2174/187569210791383947 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
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