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Current Psychiatry Reviews


ISSN (Print): 1573-4005
ISSN (Online): 1875-6441

Review: Involvement of the Cavum Septi Pellucidi and the Fornix in the Neuropathology of Schizophrenia and Affective Disorders

Author(s): Ralf Brisch, Hendrik Bielau, Tomasz Gos, Johann Steiner, Zbigniew Jankowski, Rainer Wolf, Bernhard Bogerts, Hans-Gert Bernstein

Volume 8, Issue 2, 2012

Page: [161 - 167] Pages: 7

DOI: 10.2174/1573400511208020161

Price: $65


The septal region, including the cavum septi pellucidi (CSP), and the fornix are part of the limbic system. The majority of MRI- and postmortem studies indicate that enlarged CSP are implicated in the pathology of schizophrenia, but the majority of MRI-studies show that enlarged CSP are not involved in the pathology of bipolar and major depressive disorders. The MRI and post-mortem studies on the role of the fornix in schizophrenia point to a discrepancy in the results. Our review of the role of the CSP in schizophrenia and affective disorders summarizes 29 studies and one meta-analysis. Furthermore, our review of the involvement of the fornix in schizophrenia and affective disorders evaluates 14 studies and one meta-analysis. The discrepancies in the results of the CSP and the fornix might be explained by differences in the methods and sample sizes as well by publication bias.

Keywords: Cavum septi pellucidi, Cavum vergae, Fornix, Schizophrenia, Bipolar disorder, Major depressive disorder, Affective disorders, Magnetic resonance imaging, Postmortem study, neuroendocrine

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