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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Risk Factors for Pneumococcal Nasopharyngeal Colonization Before and After Pneumococcal Conjugate Vaccination in Persons with HIV: Brief Report

Author(s): Kristina Obrink-Hansen, Ole S. Søgaard, Zitta B. Harboe and Henrik C. Schonheyder

Volume 10, Issue 3, 2012

Page: [252 - 255] Pages: 4

DOI: 10.2174/157016212800618101

Price: $65

Abstract

HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909.

In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

Keywords: HIV, Nasopharyngeal colonization, Pneumococcal vaccination, Risk factors, Smoking, S. Pneumoniae.


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