Abstract
UDP-glucuronosyltransferases (UGTs) play important roles in the disposition of many drugs and xenobiotics. Herbal medicine, an important group of multicomponent therapeutics, is widely and increasingly used. Drug metabolism of herbal medicine mediated by cytochrome P450s has been extensively studied; however, herbal medicine metabolism mediated by UGTs has not been adequately investigated. Thus, it is necessary to evaluate current evidence on the glucuronidation of herbal medicines by UGTs. In this review, the research advances of the potential for commonly used herbal medicines as UGT substrate and modulator are summarized. In addition, the herb-drug interactions associated with UGTs are also discussed.
Keywords: UDP-glucuronosyltransferase, herbal medicines, glucuronidation, herb-drug interaction, Phytochemical Metabolism, Associated Herb-Drug Interactions, UGTs, multicomponent therapeutics, Drug metabolism, herbal medicine, cytochrome P450s, glucuronidation, morphine
Current Drug Metabolism
Title:Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions
Volume: 13 Issue: 5
Author(s): Li Li, Haihong Hu, Siyun Xu, Quan Zhou and Su Zeng
Affiliation:
Keywords: UDP-glucuronosyltransferase, herbal medicines, glucuronidation, herb-drug interaction, Phytochemical Metabolism, Associated Herb-Drug Interactions, UGTs, multicomponent therapeutics, Drug metabolism, herbal medicine, cytochrome P450s, glucuronidation, morphine
Abstract: UDP-glucuronosyltransferases (UGTs) play important roles in the disposition of many drugs and xenobiotics. Herbal medicine, an important group of multicomponent therapeutics, is widely and increasingly used. Drug metabolism of herbal medicine mediated by cytochrome P450s has been extensively studied; however, herbal medicine metabolism mediated by UGTs has not been adequately investigated. Thus, it is necessary to evaluate current evidence on the glucuronidation of herbal medicines by UGTs. In this review, the research advances of the potential for commonly used herbal medicines as UGT substrate and modulator are summarized. In addition, the herb-drug interactions associated with UGTs are also discussed.
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Cite this article as:
Li Li, Hu Haihong, Xu Siyun, Zhou Quan and Zeng Su, Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions, Current Drug Metabolism 2012; 13 (5) . https://dx.doi.org/10.2174/1389200211209050615
DOI https://dx.doi.org/10.2174/1389200211209050615 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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