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Current Molecular Pharmacology


ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Potential Anti-Catabolic and Anabolic Properties of Strontium Ranelate

Author(s): Romuald Mentaverri, Michel Brazier, Said Kamel and Patrice Fardellone

Volume 5, Issue 2, 2012

Page: [189 - 194] Pages: 6

DOI: 10.2174/1874467211205020189

Price: $65


Osteoporosis is a major public health problem for adults above 55 years of age, which leads to an increase in bone fragility. Last decade has witnessed remarkable advances in molecular biology and genetics that led to detailed understanding of the bone remodeling cycle and new therapeutic targets for its treatment have emerged. Thus, besides classical approach (vitamin D and calcium administration, bisphosphonates, oestrogen, raloxifene), new therapeutic agents such as parathyroid hormone (PTH) compounds, anti-RANKL antibodies and strontium ranelate are or will be increasingly used in the treatment of osteoporosis. In this review, we have presented the importance and therapeutic potential of strontium ranelate as a dual agent in the current treatment of osteoporosis.

Keywords: Biological markers, Bone cells activity, Bone remodeling, Strontium Ranelate

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