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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Tumor Necrosis Factor-Alpha Monoclonal Antibodies for Crohns Disease: Tipping the Balance

Author(s): Silvio Danese, Nico Pagano, Erika Angelucci, Tommaso Stefanelli, Alessandro Repici, Paolo Omodei, Marco Daperno and Alberto Malesci

Volume 14, Issue 14, 2007

Page: [1489 - 1497] Pages: 9

DOI: 10.2174/092986707780831104

Price: $65


Crohns disease (CD) is a chronic inflammatory disorder which may involve any part of gastrointestinal tract. Chronic inflammation is primarily due to an immunological imbalance between pro- and anti-inflammatory cytokines, and with a defective apoptosis of lamina propria T cells. Amongst the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) seems to play a central role in pathogenesis of CD. Over the last years, increasing knowledge on the pathogenesis of CD together with progresses in bio-technology have led to the development of a number of biological agents targeting specific molecules involved in gut inflammation, most importantly TNF-α and its receptors. The aim of this paper is to critically review the rationale and state-of-the art for the use TNF-α inhibitors in the treatment of CD.

Keywords: Infliximab, TNF receptors, Lipopolysaccaride, Toll-like receptors, T lymphocytes, Certolizumab pegol

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