Abstract
3-n-Butylphthalide (1) and its analogues, which are the main components in the volatile oil of celery as well as a wide range of umbelliferae and composite plants, have potential applications as hypotensive drugs because of their strong pharmacological activities, such as improving the microcirculatory system of mans brain, improving nervous function deficiency, antiasthma, anticonvulsion, inhibiting platelet aggregation, inhibiting prostaglandin (PG) F2a growth, enhancing blood flow volume, antitumorigenesis, hypotensive activity and so on, so the investigation on the syntheses and applications of them has attracted considerable attention. The significant synthetic methods of 3-n-butylphthalide and its analogues were summarized and discussed in this review and it is expected that it may be valuable for their further development and applications.
Keywords: Benzoyl Chloride, o-Bromobenzaldehyde, Enyne-Diyne System, Chiral Phthalide, 3-Butylidenephthalide
Current Organic Chemistry
Title: Progress in Syntheses of 3-n-Butylphthalide and Its Analogues
Volume: 11 Issue: 9
Author(s): Mo Jun Xiong and Zhong Hui Li
Affiliation:
Keywords: Benzoyl Chloride, o-Bromobenzaldehyde, Enyne-Diyne System, Chiral Phthalide, 3-Butylidenephthalide
Abstract: 3-n-Butylphthalide (1) and its analogues, which are the main components in the volatile oil of celery as well as a wide range of umbelliferae and composite plants, have potential applications as hypotensive drugs because of their strong pharmacological activities, such as improving the microcirculatory system of mans brain, improving nervous function deficiency, antiasthma, anticonvulsion, inhibiting platelet aggregation, inhibiting prostaglandin (PG) F2a growth, enhancing blood flow volume, antitumorigenesis, hypotensive activity and so on, so the investigation on the syntheses and applications of them has attracted considerable attention. The significant synthetic methods of 3-n-butylphthalide and its analogues were summarized and discussed in this review and it is expected that it may be valuable for their further development and applications.
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Cite this article as:
Mo Jun Xiong and Zhong Hui Li , Progress in Syntheses of 3-n-Butylphthalide and Its Analogues, Current Organic Chemistry 2007; 11 (9) . https://dx.doi.org/10.2174/138527207780831738
DOI https://dx.doi.org/10.2174/138527207780831738 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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