Abstract
The high distribution of CB2 receptors in immune cells suggests their important role in the control of inflammation. Growing evidence offers this receptor as an attractive therapeutic target: CB2 selective agonists are able to modulate inflammation without triggering psychotropic effects. This review will summarize the literature on the implication of CB2 in inflammation and CB2 selective agonists with anti-inflammatory activity.
Keywords: cannabinoids, CB2 receptors, CB2 agonists, inflammation, anti-inflammatory agents, central nervous system inflammation, chronic inflammatory diseases, IBD, Crohn’s disease, ulcerative colitis, ischemia/reperfusion injury, aminoalkylindoles, tricyclic pyrazoles, morpholines, quinolones
Current Medicinal Chemistry
Title:Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents
Volume: 19 Issue: 21
Author(s): N. Leleu-Chavain, M. Body-Malapel, J. Spencer, P. Chavatte, P. Desreumaux and R. Millet
Affiliation:
Keywords: cannabinoids, CB2 receptors, CB2 agonists, inflammation, anti-inflammatory agents, central nervous system inflammation, chronic inflammatory diseases, IBD, Crohn’s disease, ulcerative colitis, ischemia/reperfusion injury, aminoalkylindoles, tricyclic pyrazoles, morpholines, quinolones
Abstract: The high distribution of CB2 receptors in immune cells suggests their important role in the control of inflammation. Growing evidence offers this receptor as an attractive therapeutic target: CB2 selective agonists are able to modulate inflammation without triggering psychotropic effects. This review will summarize the literature on the implication of CB2 in inflammation and CB2 selective agonists with anti-inflammatory activity.
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Cite this article as:
Leleu-Chavain N., Body-Malapel M., Spencer J., Chavatte P., Desreumaux P. and Millet R., Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents, Current Medicinal Chemistry 2012; 19 (21) . https://dx.doi.org/10.2174/092986712801323207
DOI https://dx.doi.org/10.2174/092986712801323207 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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