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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

22% Co/CeO2-ZrO2-catalyzed Synthesis of 1, 2, 3, 4-tetrahydro-2- pyrimidinones and -thiones

Author(s): Hajar Biklarian, Farahnaz K. Behbahani and Zahra Fakhroueian

Volume 9, Issue 8, 2012

Page: [580 - 584] Pages: 5

DOI: 10.2174/157017812802850159

Price: $65


Three-component condensation reaction of an aldehyde with β-ketoester and urea or thiourea in acetonitrile to afford the dihydropyrimidinones and thions (DHPMs) in the presence of 22% Co/CeO2-ZrO2 nano fine particle as a novel, reusable and green catalyst is reported. Utilizing of 22% Co/CeO2-ZrO2 nano fine particle catalyst also offers a cleaner process in that it can be reused and will not bring additional pollutants into the “environment” that is agreeable green chemistry point of view.

Keywords: 22% Co/CeO2-ZrO2, aldehydes, dihydropyrimidinones, 4-dihydropyrimidin-2, calcium, neuropeptide, thiones, HIV, anti-inflammatory, antihypertensive.

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