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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Fluconazole Pharmacokinetics and Safety in Premature Infants

Author(s): K. Turner, P. Manzoni, D. K. Benjamin, M. Cohen-Wolkowiez, P. B. Smith and M. M. Laughon

Volume 19, Issue 27, 2012

Page: [4617 - 4620] Pages: 4

DOI: 10.2174/092986712803306367

Price: $65


Invasive candidiasis (IC) in the premature infant population is a common infection that results in substantial morbidity and mortality. For these patients, fluconazole is among the first line therapies to treat and prevent IC, and yet few prospective studies investigating its pharmacokinetics (PK) and safety have been performed in this vulnerable population. We review five phase I studies examining the PK of fluconazole in premature infants, which demonstrate markedly differing kinetics compared to adults. Based on these data, a treatment dose of 12mg/kg/day, with the potential need of a loading dose of 25mg/kg to achieve rapid steady state concentrations, achieves surrogate pharmacodynamic targets. Additionally, fluconazole appears to be safe to use in this population, with only minimal reversible hepatobiliary effects.

Keywords: Fluconazole, infant, premature, preterm, safety, pharmacokinetics, candida, infection, treatment, neonate.

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