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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Utility of Assessing Thiopurine S-methyltransferase Polymorphisms Before Azathioprine Therapy

Author(s): Teresa Cabaleiro, Manuel Roman, Javier P. Gisbert and Francisco Abad-Santos

Volume 13, Issue 9, 2012

Page: [1277 - 1293] Pages: 17

DOI: 10.2174/138920012803341311

Price: $65


Thiopurine S-methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs, such as azathioprine and mercaptopurine, which are used in a variety of diseases. Several mutations in the TPMT gene correlate with low enzyme activity and subsequent adverse effects, mainly myelotoxicity. Hence, genotyping TPMT makes it possible to identify patients at high risk of drug toxicity and adjust dosage accordingly. However, further research about the availability of a reliable and universal screening method and more costeffectiveness studies are necessary.

Keywords: Thiopurine S-methyltransferase, azathioprine, polymorphism, genotyping

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