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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Potential Role of TRAIL in the Management of Autoimmune Diabetes Mellitus

Author(s): Stella Bernardi, Alessia Norcio, Barbara Toffoli, Giorgio Zauli and Paola Secchiero

Volume 18, Issue 35, 2012

Page: [5759 - 5765] Pages: 7

DOI: 10.2174/138161212803530925

Price: $65


Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to the immune-mediated destruction of pancreatic -cells, whose incidence has been steadily increasing during the last decades. Insulin replacement therapy can treat T1DM, which, however, is still associated with substantial morbidity and mortality. For this reason, great effort is being put into developing strategies that could eventually prevent and/or cure this disease. These strategies are mainly focused on blocking the immune system from attacking -cells together with functional islet restoration either by regeneration or transplantation. Recent experimental evidences suggest that TNFrelated apoptosis-inducing ligand (TRAIL), which is an immune system modulator protein, could represent an interesting candidate for the cure for T1DM and/or its complications. Here we review the evidences on the potential role of TRAIL in the management of T1DM.

Keywords: Autoimmune diabetes mellitus, TRAIL, apoptosis, signal transduction

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