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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Cellular Mechanisms of Brain Injury and Cell Death

Author(s): Armin Schubert and Logan Emory

Volume 18, Issue 38, 2012

Page: [6325 - 6330] Pages: 6

DOI: 10.2174/138161212803832425

Price: $65


An array of clinical events may lead to perioperative neurological injury. We first review the general cellular mechanisms leading to brain tissue injury and death. The genesis and mechanisms of injury after cerebral aneurysm surgery, traumatic brain injury, postoperative vascular insult in patients with severe cerebrovascular disease are discussed, as are strategies for prevention and treatment. More has become known about the epidemiology, risk factors and potential preventive strategies in postoperative delirium, and, to a lesser extent, postoperative cognitive dysfunction. Finally, emerging concepts in clinical brain protection are discussed, including preconditioning, gene therapy and stem cells.

Keywords: Hypoxic brain injury, aroxic brain injury, calcium-dependent cell death excitotoxicity, apoptosis, oxygen radicals, inflammatory response, IHAST trial, aneurysm surgery, cerebral vasospasan, re-bleeding, traumatic brain injury, hypothermin, cognitive dysfunction preconditioning

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