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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties

Author(s): M.S. Pino-Gonzalez, N. Ona and A. Romero-Carrasco

Volume 12, Issue 14, 2012

Page: [1477 - 1484] Pages: 8

DOI: 10.2174/138955712803832708

Price: $65

Abstract

The revision of the structures and properties of Calystegines shows that they can be regarded as carbohydrate mimics, with related biological activities and peculiar characteristics. Not only they can be isolated from food plants, but they can be obtained from a variety of monosaccharide derivatives and of non-carbohydrate products. Although several synthetic calystegine analogs have been reported as glycosidase inhibitors, new, more potent and effective inhibitors are required.

Keywords: Calystegine, Polydroxylated Nortropane, Polydroxylated Alkaloid, Glycosidase Inhibitor, dihydroxynortropanes, hemiaminal, biogenetic, pyrrolidines


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