Abstract
An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.
Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure
Letters in Organic Chemistry
Title:A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone
Volume: 9 Issue: 10
Author(s): Alan L. Myers, Yan-Ping Zhang, Mark A. Kramer, William G. Bornmann, Ahmed Kaseb, Peiying Yang and Hai T. Tran
Affiliation:
Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure
Abstract: An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.
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Cite this article as:
L. Myers Alan, Zhang Yan-Ping, A. Kramer Mark, G. Bornmann William, Kaseb Ahmed, Yang Peiying and T. Tran Hai, A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone, Letters in Organic Chemistry 2012; 9 (10) . https://dx.doi.org/10.2174/157017812803901890
DOI https://dx.doi.org/10.2174/157017812803901890 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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