Abstract
Gold nanoparticles stabilized with polyethylene glycol were used to study their cytotoxicity and antiviral activity against HIV-1 in the laboratory. The HeLa-CD4-LTR-B-gal cell line was used with gold nanoparticles to determine the cell viability using luminescent assay. The 50% cytotoxicity concentration, IC50 of gold nanoparticles was found to be 1.12 ± 0.05 mg/ml. M-tropic, T-tropic, dual tropic and resistant isolates were inhibited by gold nanoparticles and their inhibition concentration ranged from 0.05 to 0.12 mg/ml. The mechanism of gold nanoparticles against HIV-1 is not clear but it inhibits the HIV-1 fusion. In this study, the gold nanoparticles were used to analyze their mode of antiviral activity and the experimental results showed that they inhibit the viral entry by binding with gp120 and prevent CD4 attachment. These properties of gold nanoparticles make them as an effective antiviral inhibitor.
Keywords: Gold nanoparticle, cytotoxic, broad - spectrum, immune system, viral inhibition, HIV-1, AIDS, antiviral, inhibitor, concentration
Current HIV Research
Title:Gold Nanoparticles as an HIV Entry Inhibitor
Volume: 10 Issue: 8
Author(s): S. Vijayakumar and S. Ganesan
Affiliation:
Keywords: Gold nanoparticle, cytotoxic, broad - spectrum, immune system, viral inhibition, HIV-1, AIDS, antiviral, inhibitor, concentration
Abstract: Gold nanoparticles stabilized with polyethylene glycol were used to study their cytotoxicity and antiviral activity against HIV-1 in the laboratory. The HeLa-CD4-LTR-B-gal cell line was used with gold nanoparticles to determine the cell viability using luminescent assay. The 50% cytotoxicity concentration, IC50 of gold nanoparticles was found to be 1.12 ± 0.05 mg/ml. M-tropic, T-tropic, dual tropic and resistant isolates were inhibited by gold nanoparticles and their inhibition concentration ranged from 0.05 to 0.12 mg/ml. The mechanism of gold nanoparticles against HIV-1 is not clear but it inhibits the HIV-1 fusion. In this study, the gold nanoparticles were used to analyze their mode of antiviral activity and the experimental results showed that they inhibit the viral entry by binding with gp120 and prevent CD4 attachment. These properties of gold nanoparticles make them as an effective antiviral inhibitor.
Export Options
About this article
Cite this article as:
Vijayakumar S. and Ganesan S., Gold Nanoparticles as an HIV Entry Inhibitor, Current HIV Research 2012; 10 (8) . https://dx.doi.org/10.2174/157016212803901383
DOI https://dx.doi.org/10.2174/157016212803901383 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [ Hot topic:Metabolic Syndrome - Modern Pharmacological, Genetic, Clinical and Environmental Contributions (Guest Editor: Aldi T. Kraja)]
Endocrine, Metabolic & Immune Disorders - Drug Targets A “Cute” Desensitization of TRPV1
Current Pharmaceutical Biotechnology The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila
Current Molecular Medicine Phosphoinositide-3-kinases as the Novel Therapeutic Targets for the Inflammatory Diseases: Current and Future Perspectives
Current Drug Targets Fibroblast Growth Factor Receptor Signaling in Cancer Biology and Treatment
Current Signal Transduction Therapy Gender Differences in Pharmacokinetics and Side Effects of Second Generation Antipsychotic Drugs
Current Neuropharmacology Cannabinoids, Opioids and MDMA: Neuropsychological Interactions Related to Addiction
Current Drug Targets The Use of TNF Family Ligands and Receptors and Agents which Modify their Interaction as Therapeutic Agents
Current Drug Targets Mechanistic Approach to Understanding Psychosis Risk in Velocardiofacial Syndrome
Current Pediatric Reviews A Role for Endothelin-1 in Peripheral Vascular Disease
Current Vascular Pharmacology Drug Discovery and Protein Tyrosine Phosphatases
Current Medicinal Chemistry New Ways to Improve Breast Cancer Therapy Targeting Specific Molecular Pathways
Current Cancer Therapy Reviews Recent Advances Using Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders: Animal and Clinical Studies
Current Drug Therapy Vascular effects of flavonoids
Current Medicinal Chemistry Animal Models for Studying Neointima Formation
Current Vascular Pharmacology Medicinal Plants for Diabetes Treatment During Pregnancy
Current Medicinal Chemistry Novel Approaches to Anti-Inflammatory Agents as Therapeutics for Asthma
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Adverse Systemic Reactions of Antihistamines: Highlights in Sedating Effects, Cardiotoxicity and Drug Interactions
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents A Review of Current Strategies for Treatment Resistant Obsessive-Compulsive Disorder
Current Drug Therapy Recent Patents in Diagnosis and Treatment for Inborn Errors of Metabolism
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery