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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

Author(s): Nazha Hamdani and Wolfgang A. Linke

Volume 13, Issue 13, 2012

Page: [2522 - 2531] Pages: 10

DOI: 10.2174/1389201011208062522

Price: $65

Abstract

Heart failure is characterized by elevated circulating catecholamine levels and extensive abnormalities in β-adrenergic receptor signaling. Under physiological conditions, sympathetic modulation via catecholamines induces positive inotropic, chronotropic and lusitropic responses. Well established in heart failure patients is a pronounced activation of the sympathetic system, accompanied by downregulation and desensitization of β-adrenergic receptors, leading to a markedly diminished β-adrenergic contractile response. In this review, we will discuss the normal β-adrenergic receptor signaling pathway in the heart and focus on the pathphysiological alterations of β-adrenergic receptor signaling and contractile proteins in heart failure.

Keywords: Heart failure, β adrenergic receptors, myofilament proteins, cardiomyocytes


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