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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Natural Proteinaceous Inhibitors of Serine Proteases

Author(s): Dawid Debowski

Volume 19, Issue 6, 2013

Page: [1068 - 1084] Pages: 17

DOI: 10.2174/138161281906140714121225

Price: $65


The deregulated proteolysis is associated with various diseases in humans. Proteases are commonly regarded as the therapeutic targets. Almost one-third of all proteolytic enzymes in humans are serine proteases. This work provides a brief characteristic of the proteinaceous natural inhibitors, mostly of serine proteases. The examples of some classical and recently identified canonical and noncanonical inhibitors as well as serpins are described. Their actual and potential therapeutic applications are discussed.

Keywords: Serine proteases, canonical, non-canonical inhibitors, serpins.

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