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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Author(s): Annalaura Barbieri, Claudio Franceschi, Miriam Capri, Aurelia Santoro, Fiammetta Biondi, Maria Scurti, Elisa Pini, Elisa Cevenini, Morena Martucci, Elena Bellavista, Dario Vianello, Vincenzo Borelli, Laura Lomartire, Stefano Salvioli, Stella Lukas Yani, Federica Sevini, Laura Bucci, Rita Ostan, Elisa Fontanesi, Cristina Giuliani, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Maria Conte, Catia Lanzarini and Daniela Monti

Volume 19, Issue 9, 2013

Page: [1675 - 1679] Pages: 5

DOI: 10.2174/1381612811319090015


Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

Keywords: Inflammation, aging, centenarians, cell senescence, immunosenescence, immunological stimuli, pro-inflammatory mediators, markers, inflamm-aging, longevity

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