Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Fish Oils and Vascular Disease Prevention: An Update

Author(s): K. Tziomalos, V. G. Athyros, D. P. Mikhailidis, K. Tziomalos, V. G. Athyros and D. P. Mikhailidis

Volume 14, Issue 24, 2007

Page: [2622 - 2628] Pages: 7

DOI: 10.2174/092986707782023307

Price: $65


Considerable epidemiological data confirmed the existence of favorable associations between fish consumption and mortality from cardiovascular disease.Accumulating evidence suggests that n-3 polyunsaturated fatty acids supplementation is an effective additive treatment for the primary and secondary prevention of cardiovascular disease. Another indication for the use of n-3 PUFA is the treatment of hypertriglyceridemia as monotherapy or in combination with other lipid lowering agents (e.g. statins or fibrates). However, high doses of n-3 PUFA are required for this effect (e.g. 3-4 g/day). Fish oils may be acting via several mechanisms that include antiarrhythmic, antithrombotic and anti-inflammatory effects as well as plaque stabilization. Despite the current evidence supporting a beneficial effect of fish oils on vascular disease, more definitive studies than the ones already performed are required. Some ongoing trials may provide further insight into the indications for fish oil supplementation. This review considers the mechanisms accounting for the cardioprotective properties of n-3 polyunsaturated fatty acids. We also discuss the epidemiological and interventional studies evaluating the relationship between n-3 polyunsaturated fatty acids consumption and cardiovascular disease.

Keywords: Fish oil, n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, vascular disease, diet, sudden death, triglycerides

« Previous

Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy