Abstract
Epigenetics is key to understanding modulation of gene expression at specific stages and conditions in nervous system development and function. In epigenetic processes, a variety of enzymes contribute to modify chromatin with methyl, acetyl or other chemical marks, leading to repression or activation of the targeted gene without altering the original sequence. Aberrant activities of these epigenetic enzymes are implicated in many nervous system diseases, including neurodevelopmental disorders, brain cancer, neurodegenerative diseases, and mental illnesses. Thus, they have emerged as new targets for treating a variety of nervous system disorders. In this review, we briefly summarize the association between various epigenetic mechanisms and discuss recent progress in drug discovery efforts involving epigenetic regulators.
Keywords: DNA methyltransferase, epigenetics, glioma, histone deacetylase, histone methyltransferase, nervous system disease, neurodevelopmental disease, neurodegenerative disease
CNS & Neurological Disorders - Drug Targets
Title:Targeting Epigenetics in Nervous System Disease
Volume: 12 Issue: 1
Author(s): Ruihan Zhang, Junyan Lu, Xiangqian Kong, Lu Jin and Cheng Luo
Affiliation:
Keywords: DNA methyltransferase, epigenetics, glioma, histone deacetylase, histone methyltransferase, nervous system disease, neurodevelopmental disease, neurodegenerative disease
Abstract: Epigenetics is key to understanding modulation of gene expression at specific stages and conditions in nervous system development and function. In epigenetic processes, a variety of enzymes contribute to modify chromatin with methyl, acetyl or other chemical marks, leading to repression or activation of the targeted gene without altering the original sequence. Aberrant activities of these epigenetic enzymes are implicated in many nervous system diseases, including neurodevelopmental disorders, brain cancer, neurodegenerative diseases, and mental illnesses. Thus, they have emerged as new targets for treating a variety of nervous system disorders. In this review, we briefly summarize the association between various epigenetic mechanisms and discuss recent progress in drug discovery efforts involving epigenetic regulators.
Export Options
About this article
Cite this article as:
Zhang Ruihan, Lu Junyan, Kong Xiangqian, Jin Lu and Luo Cheng, Targeting Epigenetics in Nervous System Disease, CNS & Neurological Disorders - Drug Targets 2013; 12 (1) . https://dx.doi.org/10.2174/1871527311312010018
DOI https://dx.doi.org/10.2174/1871527311312010018 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pyruvate Kinase M2: Regulatory Circuits and Potential for Therapeutic Intervention
Current Pharmaceutical Design Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes
Current Radiopharmaceuticals Repurposed Drugs in Metabolic Disorders
Current Topics in Medicinal Chemistry Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs
Current Medicinal Chemistry Procyanidin B2 3,3″-di-O-gallate Inhibits Endothelial Cells Growth and Motility by Targeting VEGFR2 and Integrin Signaling Pathways
Current Cancer Drug Targets The Peripheral Benzodiazepine Receptor: A Promising Therapeutic Drug Target
Current Medicinal Chemistry Small Molecule Complementarity As A Source of Novel Pharmaceutical Agents and Combination Therapies
Current Pharmaceutical Design Target Based Drug Design - A Reality in Virtual Sphere
Current Medicinal Chemistry MicroRNA Dysregulation in Gastric Cancer
Current Pharmaceutical Design Therapeutic Use of Molecules that Mimic Pathogen Danger Signals
Endocrine, Metabolic & Immune Disorders - Drug Targets Multiple VEGF Family Members are Simultaneously Expressed in Ovarian Cancer: a Proposed Model for Bevacizumab Resistance
Current Pharmaceutical Design Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line
Current Pharmaceutical Biotechnology Intracellular Delivery of Potential Therapeutic Genes: Prospects in Cancer Gene Therapy
Current Gene Therapy Clinical Applications of Choline PET/CT in Brain Tumors
Current Pharmaceutical Design Oncolytic Viruses for Induction of Anti-Tumor Immunity
Current Pharmaceutical Biotechnology Targeted Vascular Drug Delivery in Cerebral Cancer
Current Pharmaceutical Design Editorial [Hot Topic: ADAMs: Targets for Drug Discovery (Executive Editor: Marcia L. Moss)]
Current Pharmaceutical Design Development of Heparanase Inhibitors for Anti-Cancer Therapy
Current Medicinal Chemistry New Trends of Deep Learning in Clinical Cardiology
Current Bioinformatics Aluminum Vaccine Adjuvants: Are they Safe?
Current Medicinal Chemistry