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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Radiolabeled Iron Oxide Nanoparticles As Dual-Modality SPECT/MRI and PET/MRI Agents

Author(s): Penelope Bouziotis, Dimitrios Psimadas, Theodoros Tsotakos, Dimosthenis Stamopoulos and Charalampos Tsoukalas

Volume 12, Issue 23, 2012

Page: [2694 - 2702] Pages: 9

DOI: 10.2174/1568026611212230007

Price: $65


Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.

Keywords: Magnetic nanoparticles, iron oxide, radiolabeling, dual modality imaging, SPECT/MRI, PET/MRI

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