Abstract
Adiponectin, a newly discovered adipose-tissue secreting hormone, is a major regulator of a wide spectrum of physiological processes, such as energy metabolism, inflammation and vascular homeostasis. Emerging data suggest that adiponectin is the link between obesity and obesity-related disorders with cardiovascular disease. Adiponectin is a dominant insulin-sensitive adipokine and, in contrast to other adipose-tissue derived cytokines, it has major anti-diabetic, antiatherogenic and anti-inflammatory properties. Adiponectin has been extensively studied in the context of several aspects and risk factors of cardiovascular disease such as obesity, diabetes type I and II, coronary heart disease, hypertension, heart failure, cerebrovascular disease and smoking. The aim of this article is to summarize the acquired so far knowledge on adiponectin in relation to cardiovascular disease, to review its main biological and biochemical characteristics, to highlight the main mechanisms of adiponectin-driven beneficial effects on vasculature and briefly to refer to the basic correlations of adiponectin with the important aforementioned aspects of cardiovascular disease.
Keywords: Adiponectin, biomarker, cardiovascular disease, coronary artery disease, diabetes mellitus, heart failure, hypertension, obesity, metabolic syndrome
Current Topics in Medicinal Chemistry
Title:Adiponectin: Merely a Bystander or the Missing Link to Cardiovascular Disease?
Volume: 13 Issue: 2
Author(s): Georgios Hatzis, Spyridon Deftereos, Dimitris Tousoulis, Georgios Bouras, Georgios Giannopoulos, Nikolaos Anatoliotakis, Dimitrios Tsounis and Christodoulos Stefanadis
Affiliation:
Keywords: Adiponectin, biomarker, cardiovascular disease, coronary artery disease, diabetes mellitus, heart failure, hypertension, obesity, metabolic syndrome
Abstract: Adiponectin, a newly discovered adipose-tissue secreting hormone, is a major regulator of a wide spectrum of physiological processes, such as energy metabolism, inflammation and vascular homeostasis. Emerging data suggest that adiponectin is the link between obesity and obesity-related disorders with cardiovascular disease. Adiponectin is a dominant insulin-sensitive adipokine and, in contrast to other adipose-tissue derived cytokines, it has major anti-diabetic, antiatherogenic and anti-inflammatory properties. Adiponectin has been extensively studied in the context of several aspects and risk factors of cardiovascular disease such as obesity, diabetes type I and II, coronary heart disease, hypertension, heart failure, cerebrovascular disease and smoking. The aim of this article is to summarize the acquired so far knowledge on adiponectin in relation to cardiovascular disease, to review its main biological and biochemical characteristics, to highlight the main mechanisms of adiponectin-driven beneficial effects on vasculature and briefly to refer to the basic correlations of adiponectin with the important aforementioned aspects of cardiovascular disease.
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Cite this article as:
Hatzis Georgios, Deftereos Spyridon, Tousoulis Dimitris, Bouras Georgios, Giannopoulos Georgios, Anatoliotakis Nikolaos, Tsounis Dimitrios and Stefanadis Christodoulos, Adiponectin: Merely a Bystander or the Missing Link to Cardiovascular Disease?, Current Topics in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1568026611313020005
DOI https://dx.doi.org/10.2174/1568026611313020005 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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