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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering

Author(s): Greg M. Harris, Katy Rutledge, Qingsu Cheng, James Blanchette and Ehsan Jabbarzadeh

Volume 19, Issue 19, 2013

Page: [3456 - 3465] Pages: 10

DOI: 10.2174/1381612811319190011

Price: $65


There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.

Keywords: Angiogenesis, tissue engineering, bone, scaffold, microscale patterning, growth factor delivery, cell transplantation.

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