Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

George V.      Teplov; Evgeny V.      Suslov; Vladimir V.      Zarubaev; Anna A.      Shtro; Liubov A.      Karpinskaya; Artem D.      Rogachev; Dina V.      Korchagina; Konstantin P.      Volcho; Nariman F.      Salakhutdinov; Oleg I.      Kiselev

doi:10.2174/1570180811310060002

Abstract

A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

Keywords: Adamantyamine, Antiviral, (H1N1)pdm09, Influenza, Monoterpenoid, Resistance.

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Letters in Drug Design & Discovery

Title:Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

Volume: 10 Issue: 6

Author(s): George V. Teplov, Evgeny V. Suslov, Vladimir V. Zarubaev, Anna A. Shtro, Liubov A. Karpinskaya, Artem D. Rogachev, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov and Oleg I. Kiselev

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Keywords: Adamantyamine, Antiviral, (H1N1)pdm09, Influenza, Monoterpenoid, Resistance.

Abstract: A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

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Teplov George V., Suslov Evgeny V., Zarubaev Vladimir V., Shtro Anna A., Karpinskaya Liubov A., Rogachev Artem D., Korchagina Dina V., Volcho Konstantin P., Salakhutdinov Nariman F. and Kiselev Oleg I., Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060002