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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Fluorescence Imaging of Tumors In Vivo

Author(s): Byron Ballou, Lauren A. Ernst and Alan S. Waggoner

Volume 12, Issue 7, 2005

Page: [795 - 805] Pages: 11

DOI: 10.2174/0929867053507324

Price: $65


We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.

Keywords: animals, antibodies, monoclonal, antigens, neoplasm, fluorescent dyes, green fluorescent protein, imaging, nanotechnology, quantum dots

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