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Current Drug Therapy


ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Microbicides for Prevention of AIDS

Author(s): Ram S. Thakur and Arshad B. Khan

Volume 8, Issue 1, 2013

Page: [59 - 67] Pages: 9

DOI: 10.2174/1574885511308010007

Price: $65


Microbicides as a potential intervention strategy for preventing human immunodeficiency virus (HIV) transmission, provide women with a preventive option against HIV. For more than two decades, various studies have endeavored to find effective and safe microbicides, which would provide defense against HIV/AIDS. Microbicides include various agents having different mechanisms such as, disruption of cellular and microbial membranes (surfactants), restoration of the natural acidic protective pH of the vagina (acid buffers), interference interactions between HIV envelope proteins and cellular receptors (anionic polymers), and anti retroviral agents. This review presents the progress in development of microbicides in prevention of spread of HIV.

Keywords: AIDS, HIV, microbicides.

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