Abstract
The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk between Notch and microRNAs. As a key component of the Notch-mediated transcription complex, Notch can regulate expression of a number of microRNAs; at the same time, Notch ligands, Notch receptor or Notch effectors are also subject to regulation by microRNAs. Thus, a better understanding of how Notch signaling interacts with microRNAs in the context of cancer will help identify novel biomarkers and therapeutic targets. In this review, we update on recent findings on microRNAs interacting with Notch signaling at various levels, leading to tumorigenesis or chemoresistance. We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs.
Keywords: Notch signaling, microRNAs, tumorigenesis, gene silencing.
Current Drug Targets
Title:Notch-Associated MicroRNAs in Cancer
Volume: 14 Issue: 10
Author(s): Yin-Yuan Mo, Hua Tang and Lucio Miele
Affiliation:
Keywords: Notch signaling, microRNAs, tumorigenesis, gene silencing.
Abstract: The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk between Notch and microRNAs. As a key component of the Notch-mediated transcription complex, Notch can regulate expression of a number of microRNAs; at the same time, Notch ligands, Notch receptor or Notch effectors are also subject to regulation by microRNAs. Thus, a better understanding of how Notch signaling interacts with microRNAs in the context of cancer will help identify novel biomarkers and therapeutic targets. In this review, we update on recent findings on microRNAs interacting with Notch signaling at various levels, leading to tumorigenesis or chemoresistance. We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs.
Export Options
About this article
Cite this article as:
Mo Yin-Yuan, Tang Hua and Miele Lucio, Notch-Associated MicroRNAs in Cancer, Current Drug Targets 2013; 14 (10) . https://dx.doi.org/10.2174/13894501113149990188
DOI https://dx.doi.org/10.2174/13894501113149990188 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Angiogenesis in the Treatment of Genito-Urinary Cancers: Last Updates
Current Angiogenesis (Discontinued) Suppressing Glioblastoma Stem Cell Function by Aldehyde Dehydrogenase Inhibition with Chloramphenicol or Disulfiram as a New Treatment Adjunct: A Hypothesis
Current Stem Cell Research & Therapy New Prognostic Markers and Potential Therapeutic Targets in Human Testicular Germ Cell Tumors
Current Medicinal Chemistry Importance of Wnt Signaling in the Tumor Stroma Microenvironment
Current Cancer Drug Targets New Insights into HLA-G and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Mycotoxins Levels in Human Milk: A Menace to Infants and Children Health
Current Nutrition & Food Science Cadmium and Its Epigenetic Effects
Current Medicinal Chemistry Bestatin as an Experimental Tool in Mammals
Current Drug Metabolism Aminopeptidase N (APN/CD13) as a Target for Anti-Cancer Agent Design
Current Medicinal Chemistry Polyphenols Beyond Barriers: A Glimpse into the Brain
Current Neuropharmacology Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems
Current Pharmaceutical Biotechnology Cubilin, the Intrinsic Factor-Vitamin B12 Receptor in Development and Disease
Current Medicinal Chemistry Membrane and Soluble Forms of Endoglin in Preeclampsia
Current Molecular Medicine Preface
Current Molecular Medicine Relaxin-Like Peptides in Neoplastic Lesions
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Targeting the L-Arginine-Nitric Oxide Pathway for Cancer Treatment
Current Pharmaceutical Design Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue
Current Pharmaceutical Design Placental Transport of Folate and Thiamine: A Mini-Review
Current Women`s Health Reviews Targeting Plasminogen Activator Inhibitor-1: Role in Cell Signaling and the Biology of Domain-Specific Knock-in Mice
Current Drug Targets MicroRNA in Cervical Carcinogenesis: Window of Therapeutic Potential
Current Women`s Health Reviews