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The Natural Products Journal


ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Effects of Senna didymobotrya Root Extract and Compounds on Tritoninduced Hyperlipidaemic Rats and Differentiation of 3T3-Li Preadipocytes

Author(s): Charles O. Ochieng, Atul Shrivastava, Upma Chaturvedi, Ravi Sonkar, Ashok K. Khanna, Gitika Bhatia, Rakesh K. Asthana, Philip O. Owuor, Lawrence A. Manguro and Anil K. Saxena

Volume 3, Issue 3, 2013

Page: [212 - 217] Pages: 6

DOI: 10.2174/22103155113039990011

Price: $65


The lipid lowering effects of Senna didymobotrya (Leguminoceae) root extract (250 mg/kg) and pure isolates (100 mg/kg) were investigated for hypolipidemic activity on Triton-induced hyperlipidemic rats (in-vivo). The extracts and isolates showed significant (p≤0.01) reduction in serum lipid contents, and reactivation of the lipolytic enzymes, relative to the Triton-treated group. Ethyl acetate extract exhibited the highest lipid lowering (p≤0.01) compared to other fractions. Seven anthraquinones, obtusifolin (1), 1,6-di-O-methylemodin (2), nataloemodin-8-methyl ether (3), chrysophanol (4), physcion (5), chrysophanol-10,10'-bianthrone (6), physcion-10,10-bianthrone (7) and stigmasterol (8) were isolated from the ethyl acetate extract. Compounds 3, 5 and 7 displayed significant (p≤0.01) lipid lowering effects. The hypolipidaemic activities prompted the determination of inhibition of differentiation of 3T3-L1 preadipocytes into adipocytes by the compounds 3, 5 and 7. Only compound 7 exhibited potent anti-adipogenic activity without significant cytotoxicity. The result indicated that extracts of S. didymobotrya root extract can provide good antidyslipidaemic and adipocytes maturation inhibitors.

Keywords: Adipogenesis, antioxidants, hyperlipidaemia, leguminocea, senna didymobotrya.

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