Abstract
It is widely accepted that sigma ( σ) receptors represent a new and different avenue in the possible pharmacological treatment of cancer and several brain-related disorders. Of the two different σ receptor types the σ1 receptors are assumed to be of major impact for brain diseases. Molecular imaging of brain σ1 receptors with positron emission tomography (PET) or single photon emission computed tomography (SPECT) may provide a significant contribution to the understanding of the cross-talk between σ1 receptors and inter- and intracellular signalling systems. New insights into these functional interrelationships will allow a better diagnosis of brain and cancerous diseases and direct a rational development of new therapeutic concepts.
Keywords: Brain, chaperone, cancer, disease, fluspidine, molecular imaging, positron emission tomography, sigma receptor, signalling, single photon emission computed tomography, therapy.
Current Medicinal Chemistry
Title:Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives
Volume: 21 Issue: 1
Author(s): P. Brust, W. Deuther-Conrad, K. Lehmkuhl, H. Jia and B. Wünsch
Affiliation:
Keywords: Brain, chaperone, cancer, disease, fluspidine, molecular imaging, positron emission tomography, sigma receptor, signalling, single photon emission computed tomography, therapy.
Abstract: It is widely accepted that sigma ( σ) receptors represent a new and different avenue in the possible pharmacological treatment of cancer and several brain-related disorders. Of the two different σ receptor types the σ1 receptors are assumed to be of major impact for brain diseases. Molecular imaging of brain σ1 receptors with positron emission tomography (PET) or single photon emission computed tomography (SPECT) may provide a significant contribution to the understanding of the cross-talk between σ1 receptors and inter- and intracellular signalling systems. New insights into these functional interrelationships will allow a better diagnosis of brain and cancerous diseases and direct a rational development of new therapeutic concepts.
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Cite this article as:
Brust P., Deuther-Conrad W., Lehmkuhl K., Jia H. and Wünsch B., Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives, Current Medicinal Chemistry 2014; 21 (1) . https://dx.doi.org/10.2174/09298673113209990214
DOI https://dx.doi.org/10.2174/09298673113209990214 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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