Abstract
Magnetic Resonance Imaging (MRI) has established itself as the optimal method for assessing local staging in patients with rectal cancer. This is due to several factors including, most importantly, the ability to accurately delineate the mesorectal fascia and thus determine which rectal tumours threaten the circumferential resection margin (CRM). It is also able to assess depth of tumour penetration into the mesorectum and thus identify those tumours considered high risk for disease recurrence. MRI is the optimal imaging modality to assess local nodal involvement and extramural venous invasion, which has now been recognised as a poor prognostic factor for both local recurrence and overall survival rates. The use of MRI for evaluating tumours both during and after pre-operative therapies is of increasing importanceand can influence the timing of surgery if patients undergo pathological complete response or show aggressive disease warranting more intensive treatment. This review examines the current status of MRI in the local staging and management of rectal cancer. The focus of the review is to identify the important prognostic features demonstrated on MRI and to assess the influence of these tumour characteristics on treatment decision-making.
Keywords: Magnetic resonance imaging, Rectal Cancer, Local Staging, Prognostic Factors, Mesorectum.
Current Cancer Therapy Reviews
Title:The Role of MRI in Treatment Planning for Rectal Cancer - A Review
Volume: 9 Issue: 2
Author(s): R.K. Bott, M. Chand, G.F. Nash, R.I. Swift and G. Brown
Affiliation:
Keywords: Magnetic resonance imaging, Rectal Cancer, Local Staging, Prognostic Factors, Mesorectum.
Abstract: Magnetic Resonance Imaging (MRI) has established itself as the optimal method for assessing local staging in patients with rectal cancer. This is due to several factors including, most importantly, the ability to accurately delineate the mesorectal fascia and thus determine which rectal tumours threaten the circumferential resection margin (CRM). It is also able to assess depth of tumour penetration into the mesorectum and thus identify those tumours considered high risk for disease recurrence. MRI is the optimal imaging modality to assess local nodal involvement and extramural venous invasion, which has now been recognised as a poor prognostic factor for both local recurrence and overall survival rates. The use of MRI for evaluating tumours both during and after pre-operative therapies is of increasing importanceand can influence the timing of surgery if patients undergo pathological complete response or show aggressive disease warranting more intensive treatment. This review examines the current status of MRI in the local staging and management of rectal cancer. The focus of the review is to identify the important prognostic features demonstrated on MRI and to assess the influence of these tumour characteristics on treatment decision-making.
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Bott R.K., Chand M., Nash G.F., Swift R.I. and Brown G., The Role of MRI in Treatment Planning for Rectal Cancer - A Review, Current Cancer Therapy Reviews 2013; 9 (2) . https://dx.doi.org/10.2174/1573394711309020003
DOI https://dx.doi.org/10.2174/1573394711309020003 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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